Differential effect of obesity on the incidence of retinal vein occlusion with and without diabetes: a Korean nationwide cohort study

Dong Won Paik,Don-Il Ham,Dong Hui Lim,Tae-Young Chung,Se Woong Kang,Sang Jin Kim,Kyungdo Han

doi:10.1038/s41598-020-67375-x

Abstract

We aimed to evaluate the association between obesity and the incidence of retinal vein occlusion (RVO) with and without diabetes mellitus (DM).This is a retrospective cohort study using Korean National Health Insurance System data. The participants were 23,061,531 adults older than 20 years who received a health examination at least once between 2009 and 2012, and all patients were observed for RVO development until 2015. We used a multivariate adjusted Cox regression analysis to evaluate the association between RVO and body mass index (BMI) with and without DM. The analysis were evaluated via a hazard ratio (HR) and 95% confidence interval (CI). The age-, sex-, and multivariable-adjusted HRs for RVO were stratified by BMI. This population-based study revealed evidence that obesity has a different effect on the incidence of RVO in the presence and absence of DM.In people with DM, a lower BMI was associated with an increased risk of RVO, and a higher BMI was associated with a lower risk for RVO. In people without DM, the correlation was reversed: a lower BMI was associated with a lower risk for RVO and vice versa.

Highlights

We aimed to evaluate the association between obesity and the incidence of retinal vein occlusion (RVO) with and without diabetes mellitus (DM).This is a retrospective cohort study using Korean National Health Insurance System data
Typical atherosclerosis risk factors are commonly associated with all types of RVO, but vein occlusions can be secondary to other processes such as compression, inflammation, or vasospasm[4,5]
< 0.0001 < 00.0001 < 0.0001 < 0.0001 < 0.0001 < 0.0001 < 0.0001 < 0.0001 < 0.0001 < 0.0001 < 0.0001 p valueb < 0.0001 < 0.0001 < 0.0001 < 0.0001 < 0.0001. In this large-scale, nationwide, long-term follow-up study, we analyzed the incidence of RVO according to body mass index (BMI), DM, and metabolic status in a Korean population

Summary

Introduction

We aimed to evaluate the association between obesity and the incidence of retinal vein occlusion (RVO) with and without diabetes mellitus (DM).This is a retrospective cohort study using Korean National Health Insurance System data. Typical atherosclerosis risk factors are commonly associated with all types of RVO, but vein occlusions can be secondary to other processes such as compression, inflammation, or vasospasm[4,5]. Systemic diseases such as diabetes mellitus (DM), hyperlipidemia (HLD), and hypertension (HTN) are strongly related to the progression of RVO6. As far as we know, the association between baseline BMI with and without DM and the following risk of RVO has not yet been clarified or studied on a large scale

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