Abstract
The effect of ethacrynic acid (EA) was studied on microsomal ATPase in various tissues of the rat and in kidneys of different species. Inhibition of Na,K-ATPase in microsomes of kidney medulla and cortex was observed only at 5 × 10 −3 M EA. At concentrations of 10 −5−10 −4 M, EA caused some enhancement of Na,K-ATPase activity. Microsomal Mg-ATPase of kidney medulla and cortex was inhibited by EA at concentrations of 10 −5−10 −3 M in various rodents (rat, mouse, guinea-pig and rabbit) as well as in human and cat kidney. EA showed the same differential effect on kidney microsomal Mg-ATPase when microsomes were prepared without treatment with desoxycholate, when chloride was replaced by sulfate in the medium. EA inhibited preferentially Mg-ATPase vs Na, K-ATPase in micro-somes of rat brain and rat submaxillary gland.
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