Differential effect of current rise time on short and medium latency vestibulospinal reflexes.

Abstract

To investigate the effect of varying current rise time on galvanic-evoked short (SL) and medium (ML) latency vestibulospinal reflexes. We recorded the soleus EMG of standing subjects in response to 3 mA direct current transmastoid stimulation with a series of current ramps with rise times of 0-300 ms. Longer current rise times significantly delayed the onset of both SL (P<<0.001) and ML (P<<0.001) vestibulospinal responses, by approximately 20 and 39 ms, respectively. The SL response amplitude was reduced with increasing rise time (P<<0.001), whereas the ML response amplitude was relatively unaffected by stimulus rise time. With very slow rise times a prolonged ML response alone was evoked. Both SL and ML reflexes can be evoked by changes in vestibular activity produced by transmastoid galvanic stimulation with a ramp onset. We found a differential effect of current rise time on SL and ML vestibulospinal reflexes, suggesting different potential functional roles for the two reflexes. SL reflexes can participate in the response to abrupt disturbances only. ML reflexes are evoked by both fast and slow changes in vestibular discharge and may be particularly effective for slowly-changing disturbances.