Abstract
In rats, a single dose of alpha-methyl-p-tyrosine caused a time-dependent depletion of brain noradrenaline and dopamine levels which were found to accelerate the development and aggravate the intensity of duodenal ulcers caused by cysteamine. On the other hand, modulation of peripheral catecholamines by adrenal medullectomy resulted in significant prevention of the experimental duodenal ulcers. Intracerebroventricular injection of dopamine unlike that of noradrenaline also inhibited the development of duodenal ulcers. Parehteral administration of the two catecholamines also resulted in mild but significant reduction of intensity of duodenal ulcers. Thus, both central and peripheral catecholamines (especially dopamine) modulate the development of experimental duodenal ulcers.
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