Abstract
demographic factors, cardiovascular risk factors, APOE genotype and white matter hypertintensities (WMH), the mixed effect model revealed that the number of overall lacunes (p<0.001) and volume of WMH (p<0.001) were associated with the change of number of overall CMBs, lobar CMBs and deep CMBs. However, PiB-positivity was not related with the changes of number of overall CMBs (p1⁄40.201), lobar CMBs (p1⁄40.351) and deep CMBs (p1⁄40.292). Then we evaluated changes of CVD (lacunes) with the incident CMBs. The changes of overall lacunes, white matter lacunes and deep grey matter lacunes were significantly associated with the changes of number of overall CMBs and deep CMBs (all p<0.001). However, changes of deep grey matter lacunes were not related with the changes of lobar CMBs (p1⁄40.230) while overall lacunes (p1⁄40.016) and white matter lacunes (p1⁄40.007) were associated with lobar CMBs. Conclusions: The markers of CVD (lacunes and WMH) were related to development of both lobar and deep CMBs while PiB-positivity was not related. Especially, the changes of number of lacunes were associated with the incident CMBs.
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