Abstract
Nicardipine is one of the 1,4-dihydropyridine derivatives known as blockers for the voltage-dependent Ca 2+ channels in muscle cells. The effects of nicardipine on the neuronal functions were studied in several neuronal preparations including clonal rat pheochromocytoma (PC12) cells, rat brain synaptosomes and slices. Nicardipine failed to block the Ca 2+-dependent action potentials and the after-spike hyperpolarizations evoked by intracellularly injected current pulses in rat pheochromocytoma cells, while the high K +- stimulated Ca 2+ influx and ATP release were dose-dependently inhibited in the same cells. In rat cerebral synaptosomes and cortical slices, nicardipine showed no blockade on the high K +-stimulated Ca 2+ influx and transmitter releases. It was then suggested that the voltage-dependent Ca 2+ channels are polymorphic among tissues or even in a single cell from the viewpoint of dihydropyridine susceptibility.
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