Abstract
The effects of estrus and prolonged estradiol benzoate (EB) treatment on estrogen receptor-like immunoreactivity (ER-LI) were studied in the female Brazilian opossum ( Monodelphis domestica) brain. In general, both estrus animals and EB treated animals had reduced ER-LI in specific brain regions when compared to ovariectomized controls. These results support a down-regulatory role for estrogen in relation to its receptor in the brain, and indicate that ER-LI is differentially regulated in the Monodelphis forebrain.
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