Differential Diagnosis of MCI, Dementia and Depression—A Comparison of Different Cognitive Profiles

Abstract

Three-hundred-and-thirty-four cognitive profiles from neuropsychological examinations assessed during a 5-year period (2015 to 2020) from geriatric patients of a day clinic in the south of Germany were analyzed. For this purpose, the profiles were divided into the following subgroups: (1) Mild Cognitive Impairment, no depression (2) Onset or mild dementia, no depression (3) No cognitive deficit, depression (4) cognitively impaired (MCI, dementia) and depression. Subgroups were be compared using analysis of variance (independent variable IV: diagnostic groups, dependent variable DV: cognitive functions) to reveal specific differences that will allow a differential diagnosis. Post-hoc comparisons and a graphical representation of the cognitive profiles were also investigated. All cognitive profiles with a Mini-Mental-State-Examination (MMSE) score of 25 or more points were selected for analysis if they had complete data from the following testing procedures: MMSE, clock drawing test, Geriatric Depression Scale (GDS), Syndrom-Kurztest (SKT), Nuremberg Aging Inventory (NAI) maze test, Wechsler Adult Intelligence Scale (WAIS) similarities, Rivermead Behavioral Memory Test (RBMT) story immediate and delayed. The results will help to improve the differential diagnostic examination of older depressed people with and without cognitive impairment: Depressed patients usually have no objectifiable memory impairment and inconspicuous scores in the logical structure of thought processes, while attention was usually impaired in both depressed and demented patients.