Abstract

The differential diagnosis of chest pain is a challenging clinical experience requiring a perceptive and observant clinician. The patient is dependent on the clinician's skill in eliciting a meaningful and relevant history. The clinician must consider reasonable alternative diagnoses while providing immediate therapies to relieve the pain and maintain patient stability. Appropriate diagnostic procedures should be pursued quickly and efficiently to treat the patient effectively.

Highlights

  • Introductory Chapter: The Patient Presenting with Chest PainJohn-Ross D

  • The physiological structure formed by the circular muscles, diaphragm cruses, and phrenoesophageal ligament in the esophagogastric junction forms the lower esophageal sphincter (LES) which acts as the primary barrier function for reflux

  • After venous access, when the sheath is being advanced into the venous system, it could stretch the periosteum of the costoclavicular ligament which in turn can be uncomfortable for the patient

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Summary

Background

Chest pain is the principal reason for approximately 5% of the emergency department (ED) visits in the United States [1]. It is the most frequent reason for presentation to an emergency facility in men age 65 years and older. Part of the significance of chest pain as a presenting symptom is its association with potentially life-threatening diagnoses such as: acute myocardial infarction (AMI), pulmonary embolism, and aortic dissection, among others. The sections that follow provide a brief insight into the scope of chest pain diagnoses and the value of clinical findings in establishing a diagnosis

The differential diagnosis of chest pain
Diagnostic accuracy of symptoms and signs in acute coronary syndromes
Diagnostic accuracy of symptoms and signs in noncardiac causes of chest pain
Outcomes and implications of patients presenting with chest pain
Conclusions
Introduction
Clinicians and statistics
The characteristics of diagnostic tests
What is Bayes’ theorem
Determining pre-test probability in patients with stable chest pain
Testing modalities for the evaluation of stable chest pain
Stress echocardiography
Nuclear imaging testing
Noninvasive anatomic tests
Bayesian approach to test selection
Test selection in patients with low and high pre-test probability
Test selection in patients with intermediate pre-test probability
Appropriate use criteria and the delivery of high-value care
Limitations of the Bayesian approach
Definition
Epidemiology
Pathophysiology
Antireflux barrier dysfunction
Inadequate clearance mechanism of the esophagus
Impairment of esophageal mucosal resistance
Delay in gastric emptying
Clinical presentations
Diagnosis
Surveys
Barium contrast radiography
Nuclear scintigraphy
Esophageal pH monitoring
Endoscopic evaluation
Treatment
Lifestyle changes
Positioning
Dietary change
Pharmacological treatment
Proton pump inhibitors
H2 receptor antagonists
Antacids
Surface barrier agents
Prokinetic agents
Surgical treatment
Conflicts of interest and sources of funding
Chest pain after CIED implantation
Delayed chest pain
Musculoskeletal
Pneumothorax
Surgical site pain
Delayed cardiac perforation
Pacemaker-mediated angina
Conclusion
DeBakey classification
Newer classification
Dissect classification
Genetic disorders
Bicuspid aortic valve
Coarctation of aorta
Inflammatory or infectious conditions
Blunt chest trauma
Pregnancy and delivery
Chest pain
Transient pulse deficits
Focal neurological deficits
Blood investigations
Chest radiography
Echocardiography
Computed tomography
Measurement of the degradation products of plasma fibrin and fibrinogen
The gold-standard diagnostic modality for aortic dissection
Acute management of aortic dissection involves immediate resuscitation
Acute type A dissection
Type B aortic dissection
Long-term management
Type a aortic dissection patients
Nitric oxide: endothelial dysfunction and Takotsubo cardiomyopathy
The role of L-arginine analogues in eNOS function
Endothelial dysfunction and TC
Findings
Full Text
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