Abstract

In order to keep the benefits of a carbon treatment, the dose and biological effects induced by secondary fragments must be taken into account when simulating the treatment plan. These Monte-Carlo simulations codes are done using nuclear models that are constrained by experimental data. It is hence necessary to have precise measurements of the production rates of these fragments all along the beam path and for its whole energy range. In this context, a series of experiments aiming to measure the double differential fragmentation cross-sections of carbon on thin targets of medical interest has been started by our collaboration. In March 2015, an experiment was performed with a 50 MeV/nucleon 12 C beam at GANIL. During this experiment, energy and angular differential cross-section distributions on H, C, O, Al and nat Ti have been measured. In the following, the experimental set-up and analysis process are briefly described and some experimental results are presented. Comparisons between several exit channel models from Phits and Geant4 show great discrepancies with the experimental data. Finally, the homemade Sliipie model is briefly presented and preliminary results are compared to the data with a promising outcome.

Highlights

  • Hadrontherapy presents several benefits over conventional radiotherapy

  • Secondary fragments created by these reactions lead to a delocalization of the dose in the surrounding healthy tissues and to a mixed irradiation field of heterogeneous RBE values that will modify the biological dose distribution

  • All the double differential cross-sections were measured for every isotope from proton to 12 C, every target and angles ranging from 3◦ to 39◦

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Summary

Introduction

Hadrontherapy presents several benefits over conventional radiotherapy. It takes advantage of the energy deposition process of the charged ions by the presence of the. Secondary fragments created by these reactions lead to a delocalization of the dose in the surrounding healthy tissues and to a mixed irradiation field of heterogeneous RBE values that will modify the biological dose distribution These effects are still not well known and no nuclear model in the available generic simulation codes is able to accurately reproduce the fragment production. All the double differential cross-sections were measured for every isotope from proton to 12 C, every target and angles ranging from 3◦ to 39◦. The results will be quickly presented in form of angular distributions These distributions were integrated to calculate the production cross-sections of each isotope for comparison with a previous experiment at 95 MeV/nucleon [3]

Production cross-sections
Differential cross-sections
Monte-Carlo simulations
GEANT4 and PHITS
SLIIPIE

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