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Abstract
One hallmark feature of consolidation of episodic memory is that only a fraction of original information, which is usually in a more abstract form, is selected for long-term memory storage. How does the brain perform these differential memory consolidations? To investigate the neural network mechanism that governs this selective consolidation process, we use a set of distinct fearful events to study if and how hippocampal CA1 cells engage in selective memory encoding and consolidation. We show that these distinct episodes activate a unique assembly of CA1 episodic cells, or neural cliques, whose response-selectivity ranges from general-to-specific features. A series of parametric analyses further reveal that post-learning CA1 episodic pattern replays or reverberations are mostly mediated by cells exhibiting event intensity-invariant responses, not by the intensity-sensitive cells. More importantly, reactivation cross-correlations displayed by intensity-invariant cells encoding general episodic features during immediate post-learning period tend to be stronger than those displayed by invariant cells encoding specific features. These differential reactivations within the CA1 episodic cell populations can thus provide the hippocampus with a selection mechanism to consolidate preferentially more generalized knowledge for long-term memory storage.
Highlights
The hippocampus plays a crucial role in converting recent episodic events into long-lasting memories, a process termed memory consolidation [1,2,3,4,5]
We investigate if and how the hippocampus may engage in differential consolidation of memory patterns that were triggered by robust episodic events
A hallmark feature of long-term memory consolidation is that only a portion of original information about various episodic events becomes long-term memory
Summary
The hippocampus plays a crucial role in converting recent episodic events into long-lasting memories, a process termed memory consolidation [1,2,3,4,5]. Large-scale recording and decoding methods show that the real-time encoding patterns seem to reappear in the hippocampus within seconds-to-minutes after the animals encounter startling or emotionally charged episodic events [10,11] or fear conditioning [12] It has been shown in the trace fear conditioning paradigm that conditioned tone responses and tone-shock association patterns undergo trialdependent increase in the numbers of replay during learning, correlating tightly with increased immediate freezing [12]. This is the first evidence that links memory pattern replay with behavioral performance scores [12]. The various observed pattern replays is, in general, consistent with the explanation of its potential roles in memory consolidation
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