Differential block by [formula omitted]-hyoscyamine of the salivary and vascular responses of the dog mandibular gland to prostaglanidn F 2α

Abstract

Prostaglandin F 2α (PGF 2α) (3–300 pmol) administered to the dog mandibular gland via the glandular artery produced salivation and an increase in blood flow rate in a dose-related manner. The salivary responses to PGF 2α and to electrical stimulation of the chorda-lingual nerve were abolished by intra-arterial infusion of 1 -hyoscymine (30 nmol/min), whereas the vascular responses to both were not affected. The salivary and vasodilator responses to PGF 2α were not affected by intra-arterial infusion of hexamethonium (0.6–2 μmol/min) which abolished those to stimulation of the chordalingual nerve. These results support the prevous conclusion that PGF 2α produces the two responses by exciting the parasympathetic ganglion or postganglionic neurons in the dog mandibular gland.