Abstract
Radioreceptor binding techniques were utilized to examine the developmental appearance of μ, δ and k opioid receptors in rat brain. Significant differences were found in the relative proportions of the three receptor subtypes in neonatal and adult CNS. Whereas in adult brain μ and δ receptors were predominant, in 6 day old pups the receptors were primarily of the μ and k subtype. These results indicate that the three opioid receptors exhibit dissimilar developmental patterns.
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