Abstract
BackgroundPremature thelarche (PT) is a benevolent ailment affecting young girls. Multiple factors are reported to correlate with this condition, but the mechanisms responsible for the onset of PT have not yet been fully investigated. This study aimed to evaluate the relationship of nutrient intake, insulin resistance and lipid profile with PT.MethodsTwo hundred sixty-three girls with PT, and 222 healthy girls of similar age were enrolled into this study. Their demographics, Tanner stage of breast development, nutrient intake, insulin resistance and lipid profiles were compared.ResultsDaily protein and fat intakes, insulin resistance parameters including serum insulin-like growth factor 1, fasting glucose to insulin ratio, quantitative insulin check index and homeostasis model of assessment of insulin resistance, as well as serum levels of triacylglycerol, total cholesterol and low-density lipoprotein, were all significantly altered in PT patients. Daily intake of energy and carbohydrate, and serum level of high-density lipoprotein protein were statistically indistinguishable between PT patients and healthy controls.ConclusionChinese girls with PT are potentially insulin resistant, which warrants more clinical attention and further investigation to address the underlying etiology.
Highlights
Premature thelarche (PT) is a benevolent ailment affecting young girls
This study included 263 girls diagnosed of PT, with 222 healthy girls recruited as the control group
Between the anthropometric characteristics of the two groups, there were no significant differences in chronology age, bone age or Body mass index (BMI), indicating a comparable baseline for the rest of the study (Table 1)
Summary
Premature thelarche (PT) is a benevolent ailment affecting young girls. Multiple factors are reported to correlate with this condition, but the mechanisms responsible for the onset of PT have not yet been fully investigated. Premature thelarche (PT) usually manifests in girls below the age of 8, as isolated breast development without accelerated growth, early/advanced pubic and axillary hair development, menarche and/or bone maturation. PT is described as an endogenous originrelated disease, especially in infant girls where its onset is attributed to maternal estrogen exposure during pregnancy [9]. Several other factors, such as nutrition, ethnicity, adiposity, psychosocial and socioeconomic conditions, as well as genetic predisposition, may contribute to PT onset. The mechanisms responsible for the onset of PT in later stages of infancy are not thoroughly investigated
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