Abstract
Neuroglycopenia induced by administration of 2-deoxy-d-glucose (125–375 mg/kg) is characterized by bradycardia and increased sympathetic activity, overall release of norepinephrine, plasma epinephrine, and norepinephrine at stable arterial pressure and norepinephrine plasmatic clearance. Sympathoneural activity is markedly enhanced in the adrenal-demedullated rats, while the levels of norepinephrine and its overall spill into circulation are the same as in the intact animals. It is concluded that neuroglycopenia is accompanied by differential activation of the sympathetic system subdivisions and selective release of norepinephrine by sympathetic terminals, but not by the adrenal medullae.
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