Abstract
Abstract The presence of physiologically active principles in perfusates of chemically irritated lungs has been described by Steiner (1) and Bartosch (2). Garan (3) insufflated various hydrocarbons and ammonia into the isolated lungs of guinea pigs and found that the output of physiologically active materials, as assayed on the guinea pig gut, was greatest after treatment with ammonia. He inferred that the perfusate contained histamine on the basis that it caused the atropinized gut to contract, and showed the activity of the extract to be reduced after incubating it for 24 hr with the histaminase preparation, Torantil. Subsequent work of Schild (4) showed that the amount of active material produced from the rat's diaphragm by treatment with ammonium chloride varied with the pH of the medium and therefore that the magnitude of the release was dependent upon the fraction of undissociated ammonia present.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
