Abstract
Agonist stimulation of G protein-coupled receptors causes receptor activation, phosphorylation, β-arrestin binding and receptor internalization. Angiotensin II (AngII) causes rapid internalization of the AT 1 receptors, whereas AngII-bound AT 2 receptors do not internalize. Although the activation of the rat AT 1A receptor with AngII causes translocation of β-arrestin2 to the receptor, no association of this molecule with the AT 2 receptor can be detected after AngII treatment with confocal microscopy or bioluminescence resonance energy transfer. These data demonstrate that the two subtypes of angiotensin receptors have different mechanisms of regulation.
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