Abstract
The presence of complement fixing IgG class antibrain antibodies is a distinctive feature of multiple sclerosis (MS). Only two of the several specificities of these antibodies are yet identified. Testing a number of MS sera and CSF samples against homogenates of brain from two myelin-deficient mouse mutants, Jimpy and Quaking, and their littermate controls confirmed the occurrence of antibrain antibodies directed against both myelin-associated and non-myelin antigens.
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