Abstract
High energy irradiation of frozen rat frontal cortex was used to determine the molecular target sizes of the [ 3H]nitrendipine binding site (93 500 ± 9 700 daltons and of the voltage-dependent Ca 2+ channel (340 500 ± 34 000 daltons) determined as the K +-induced 45Ca 2+ uptake into synaptosomes. The conclusion that could be drawn from the target size analysis was that 45Ca 2+ flux occurs via a structure of molecular weight very different from that of the dihydropyridine binding site. Furthermore, it was found that [ 3H]nitrendipine binding to synaptosomes was not influenced by depolarization with K +.
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