Abstract
Small pulmonary arteries (SPA) and veins contract when alveolar pO2 is low. Hypoxic pulmonary vasoconstriction (HPV) is known to release Ca2+ from the SR in SPA. Hypoxia-induced SR Ca2+ release activates ClCa. Agonist-induced contraction in SPA increases when [Cl−]0 is reduced. However, the effects of altering Cl− flux on HPV in the pulmonary vein are not known. Here we show how changes in extracellular Cl− differentially affect SPA and venular contraction to hypoxia.
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