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Abstract
The human neuroblastoma cells SH-SY5Y were treated with the differentiation agents 12- O-tetradecanoyl-phorbol-13-acetate (TPA) or dimethyl sulfoxide (DMSO) and the muscarinic receptor subtype M 1 and M 2 RNA levels analyzed. After a decrease induced by both agents, the M 1 level gradually returned to normal in the presence of TPA but remained minimal with DMSO. As for M 2, several phases were observed with TPA, while DMSO caused a drastic increase. The data obtained with TPA were tentatively correlated with the amounts of immunoreactive PKCα. In conclusion, our results reveal: (a) differential regulation of M 1 and M 2 muscarinic receptor subtypes by either treatment; (b) opposing effects of TPA and DMSO on both subtypes.
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