Abstract
Total RNAs from the livers of rats treated with clofibrate and partially hydrogenated marine oil (PHMO) wer translated in a reticulocyte-lysate cell-free protein-synthesizing system. In clofibrate-treated rats, mRNA activity for acyl-CoA oxidase (AO), the rate-limiting enzyme of the peroxisomal β-oxidation system, was increased markedly compared with the control, whereas the increase was less than 2-fold in PHMO-treated rats. When rats were treated with both clofibrate and PHMO in vivo , an additional increase in the hepatic AO activity was observed compared with either treatment alone, suggesting that increases in the activities of peroxisomal β-oxidation in the rats treated with clofibrate and PHMO are based on two distinct mechanisms.
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