Abstract
Rats with total, dorsal or ventral ibotenic acid striatal lesions were challenged with DA agonists apomorphine and d-amphetamine. In rats with total lesions, both drugs induced an intense ipsilateral rotation, as did apomorphine in the dorsally lesioned. In Amphetamin indcuced ipsilateral rotation in ventrally lesioned rats, but this effect may represent a non-specific potentiation of spontaneous ipsilateral rotation observed in this group. These results indicate that the neostriatum of the rat is not an homogenous structure concerning the expression of rotational behavior after DA receptor stimulation.
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