Abstract
Introduction:The main purpose of the present study was to investigate whether I/D polymorphism of the ACE gene might affect metabolic changes related to the metabolic syndrome through a long-term interdisciplinary therapy in obese adolescents.Methods:In total, 125 obese adolescents who entered the interdisciplinary obesity programme were assigned to the following two subgroups: metabolic syndrome or non-metabolic syndrome. They were evaluated at baseline and after 1 year. Genomic DNA was extracted from circulating leukocytes.Results:Subjects with the II genotype in the non-metabolic syndrome group were only to increase their fat-free mass after therapy. Regarding lipid profile, subjects with ID and DD genotypes from both groups reduced their low-density lipoprotein cholesterol levels significantly. The metabolic parameters from the ID and DD genotypes of the non-metabolic syndrome group showed a significantly improved insulin response.Conclusion:In the present study, we showed that the ACE polymorphism was able to influence the fat-free mass in the I-carry allele in the non-metabolic syndrome group positively. In addition, the I-carry allele was able to improve the insulin resistance of the metabolic syndrome group significantly. These results suggest that the ACE I/D genotypes can influence, in different ways, the specific parameters of metabolism among obese adolescents submitted for long-term interdisciplinary therapy.
Highlights
The main purpose of the present study was to investigate whether I/D polymorphism of the Angiotensin-converting enzyme (ACE) gene might affect metabolic changes related to the metabolic syndrome through a long-term interdisciplinary therapy in obese adolescents
A total of 198 obese adolescents were enrolled in the programme; 125 obese adolescents (45 boys and 80 girls) completed 1 year of the interdisciplinary obesity programme and more than 75% of the treatment sessions of the Federal University of São Paulo – Escola Paulista de Medicina
The main purpose of the present study was to investigate whether the I/D polymorphism of the ACE gene might affect metabolic changes related to metabolic syndrome (MS) through a longterm interdisciplinary therapy in obese adolescents
Summary
The main purpose of the present study was to investigate whether I/D polymorphism of the ACE gene might affect metabolic changes related to the metabolic syndrome through a long-term interdisciplinary therapy in obese adolescents. Results: Subjects with the II genotype in the non-metabolic syndrome group were only to increase their fat-free mass after therapy. Conclusion: In the present study, we showed that the ACE polymorphism was able to influence the fat-free mass in the I-carry allele in the non-metabolic syndrome group positively. The I-carry allele was able to improve the insulin resistance of the metabolic syndrome group significantly These results suggest that the ACE I/D genotypes can influence, in different ways, the specific parameters of metabolism among obese adolescents submitted for long-term interdisciplinary therapy. These studies have shown a range of 10–30% of participation in the heritability of MS.[5,6,7,8]
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Schedule a callMore From: Journal of the renin-angiotensin-aldosterone system : JRAAS
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