Abstract
The aromatase inhibitor 1,4,6-androstatriene- 3,17-dione (ATD), a nonsteroidal antiandrogen (flutamide), testosterone and estradiol were administered by Silastic capsule or injection to ovariectomized female and castrate and intact male rats. The treatments were given separately or in combination to investigate the relative importance of elevations in nuclear estrogen receptor levels in hypothalamic and preoptic area target neurons for the expression of several of testosterone's neuroendocrine actions. These actions include the suppression of basal LH secretion, the stimulation of cyclic LH release, the induction of lordosis behavior, and the regulation of progestin receptor levels. Estrogen receptor levels were measured in purified nuclear pellets from the hypothalamus, preoptic area, and adenohypophysis with an in vitro [3H]estradiol exchange assay. Progestin receptors were quantified in cytosol preparations of these tissues using the synthetic progestin [3H]R5020. When exposed to t stosterone levels of...
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