Abstract
Chronic nicotine intake influences cortical excitability via functional and structural CNS changes, as known from animal experiments. Similar results have been demonstrated in humans (Lang et al. 2007). Smokers with 10 hours abstinence of nicotine showed a significant stronger inhibition in terms of short afferent inhibition (SAI) and diminished intracortical facilitation (ICF). Here we aimed to investigate if these differences of cortical excitability between smoking and not smoking individuals are caused and enhanced by nicotine consumption or if smoking individuals reduce enhanced inhibition by acute nicotine intake. Therefore different parameters of cortical excitability were recorded before and after nicotine consumption in smokers and nonsmokers.
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