Abstract
Prepubertal idiopathic hypertrichosis (PIH) is characterized by excessive growth of vellus hair. In a previous study of 17 girls with IPH, most of them showed elevated levels of androstenediol-glucuronide in serum, suggesting increased peripheral 5a reductase activity. In order to complete this study and to clarify these hormonal alterations, twenty-nine girls with PIH, ages 0.8 to 8.2 years and nine age- matched girls were studied, Dehydroepiandrosterone sulphate (DHEAS), testosterone (T), androstenediol glucuronide (Diol-G) were determined by RIA, and SHBG by DHT binding. The free androgen index (FAI) was calculated. We found three groups of patients with different androgen patterns: A) 10 girls had a normal pattern, B) 9 girls had elevated FAI and C) 7 girls had elevated Diol-G. Three girls showed elevated FAI and Diol-G and were analized separately.65% of the 29 girls with PIH showed pathologic hormonal patterns; 31% showed elevated FAI; 24% elevated Diol-G and 10% elevated FAI and Diol-G. 35% showed normal androgens, Diol-G and FAI. This study demonstrates that most of the girls with PIH exhibit pathologic hormonal patterns, although a small group of patients did not show any alteration in the parameters studied.
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