Abstract
Preeclampsia is a heterogeneous disease, and there are major differences in severity, fetal growth and poor placentation between early- and late-onset preeclampsia. Here, we examined the effect of onset period on fetal and neonatal growth in preeclampsia with a cross-sectional study including 102 pregnant women with preeclampsia visited Okayama University Hospital from 2009 to 2013. The subjects were retrospectively compared in terms of body mass index (BMI), weight gain during pregnancy, complications, weeks of delivery, neonatal body weight and BMI at birth, fetal growth restriction (FGR), small for gestational age (SGA), pathological findings in the placenta, and infant’s weight at 1 month after birth. Neonatal body weight and BMI at birth were significantly lower and the extent of FGR and the frequency of SGA were higher in early-onset group compared with late-onset group. Mean daily weight gain during the neonatal period was significantly lower in the early-onset group compared with the late-onset group, however the weight gain rate during the neonatal period in the early-onset group was higher than that in late-onset group. In conclusions, there are significant differences in fetal and neonatal growth between early- and late-onset preeclampsia and the catch up for growth might start during neonatal period.
Highlights
Preeclampsia (PE) is defined as hypertension occurring between 20 weeks of gestation and 12 weeks post-par-How to cite this paper: Mitsui, T., Masuyama, H., Eto, E., Nobumoto, E., Hayata, K. and Hiramatsu, Y. (2015) Different Fetal and Neonatal Growth between Early- and Late-Onset Preeclampsia
This study aimed to investigate the effect of onset period on fetal and neonatal growth under two possible conditions that might affect the strategy for the management of PE
We found no significant differences in the maternal physical state between these groups
Summary
Preeclampsia (PE) is defined as hypertension occurring between 20 weeks of gestation and 12 weeks post-par-How to cite this paper: Mitsui, T., Masuyama, H., Eto, E., Nobumoto, E., Hayata, K. and Hiramatsu, Y. (2015) Different Fetal and Neonatal Growth between Early- and Late-Onset Preeclampsia. (2015) Different Fetal and Neonatal Growth between Early- and Late-Onset Preeclampsia. PE is defined as hypertension accompanied by proteinuria, and it does not incidentally occur in combination with pregnancy [1] [2]. PE is thought to be a heterogeneous disease, and there are major differences in severity, fetal growth, poor placentation, and pulsed Doppler findings between early- and late-onset PE [3]-[5]. These findings suggest that there may be two different entities to consider when investigating the pathophysiology of PE. We have demonstrated that early-onset PE is mainly caused by changes to factors in the placenta by placental hypoplasia, while late-onset PE might be caused by too much of a burden on the pregnant woman’s body with obesity or metabolic syndrome [6] [7]
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