Abstract
AbstractHigh levels of ether phospholipids were found in rabbit alveolar macrophages. Choline phosphoglycerides (CPG) contained a significant amount of alkylacyl compound (32.5%). On the other hand, ethanolamine phosphoglyceride (EPG) included a very large amount of alkenylacyl compounds (61.2%). Small amounts of alkenylacyl CPG and alkylacyl EPG were also observed. The occurrence of a high amount of alkylacyl CPG may be related to the synthesis or release of platelet‐activating factor (PAF) from macrophages. Fatty chains at the 1‐ and 2‐positions in each lipid class of CPG or CPG or alkenylacyl EPG were several other. Particularly, the levels of 20∶4 (arachidonic acid) in alkylacyl CPG or alkenylacyl EPG were several times higher than those in corresponding diacyl phospholipids. Large portions of 20∶4‐containing species have alkenyl or alkyl ether moieties at their 1‐position in both CPG (73.6%) and EPG (85.9%). These results suggest the importance of ether‐containing phospholipids in rabbit alveolar macrophages.
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