Abstract
Objective To investigate the expression of HMGA1 in hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma(IHC) and its significance. Methods Immunohistochemistry (SABC method) was applied to detect HMGA1 expression in 60 HCC, 42 IHC, and 10 normal hepatic tissues. The relationship between HMGA1 expresssion and clinicpathological features of HCC and IHC was determined. Results No significant nuclear immunoreactivity was found in normal hepatic tissues, while 3.3% (2/60) of HCC, 66.7% (28/42) of IHC showed positive immunoreactivity, and there was significant difference between HCC and IHC(P = 0.000). The expression level of HMGA1 was strongly correlated with the expression level of p53 (r = 0.673, P < 0.05). The expression of HMGA1 in patients who died in one year (80.0%) was higher than that of patients lived(33.3%), and the difference was significant(P < 0.05). Conclusions HMGA1 protein level may serve as a potential diagnostic marker that differentiate HCC from IHC. HMGA1 may play an important role in the development of IHC. The high expression level of HMGA1 in IHC is strongly correlated with bad prognosis. Key words: High mobility group proteins; Hepatocellular; Carcinoma; Intrahepatic cholangiocarcinoma; Immunohistochemistry
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