Abstract
In the last decade a variety of non-lipid lowering effects of statins has been described. The aim of the study was to compare the effects of a lipophilic and a hydrophilic statin on human myocardial high-energy phosphate (HEP) metabolism measured with 31-phosphorus-magnetic resonance spectroscopy (MRS). 21 male patients with moderate to severe hypercholesterolemia were included. Patients were divided into 2 groups in a blinded fashion: group 1 received 10mg rosuvastatin, group 2 was put on 40mg simvastatin.
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