Abstract
Patients with renal disease, with normal renal function (n=42), and with impaired renal function (n=48) were compared with healthy controls (n=21). Beta thromboglobulin, high affinity platelet factor 4 and beta-2-microglobulin concentrations in the plasma were measured by means of RIA. Despite no evidence of thrombosis, beta-TG was elevated in patients with renal failure, as was beta-2-microglobulin. In contrast, HA-PF4 levels were identical in controls (5,8 ± 2,7 ng/ml), renal patients without (6,6 ± 5,5) and with (6,3 ± 5,7), renal failure. It is concluded that beta-TG is to a major extent catabolised in the kidneys, whereas HA-PF4 is not. Consequently, HA-PF4 concentration is a valid index of thrombosis even in uremic patients.
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