Abstract
BackgroundMajor outbreaks of hand, foot and mouth disease (HFMD) have been reported in China since 2008, posing a great threat to the health of children. Although many studies have examined the effect of meteorological variables on the incidence of HFMD, the results have been inconsistent. This study aimed to quantify the relationship between meteorological factors and HFMD occurrence in different climates of mainland China using spatial panel data models.MethodsAll statistical analyses were carried out according to different climate types. We firstly conducted a descriptive analysis to summarize the epidemic characteristics of HFMD from May 2008 to November 2012 and then detected the spatial autocorrelation of HFMD using a global autocorrelation statistic (Moran’s I) in each month. Finally, the association between HFMD incidence and meteorological factors was explored by spatial panel data models.ResultsThe 353 regions were divided into 4 groups according to climate (G1: subtropical monsoon climate; G2: temperate monsoon climate; G3: temperate continental climate; G4: plateau mountain climate). The Moran’s I values were significant with high correlations in most months of group G1 and G2 and some months of group G3 and G4. This suggested the existence of a high spatial autocorrelation with HFMD. Spatial panel data models were more appropriate to describe the data than fixed effect models. The results showed that HFMD incidences were significantly associated with average atmospheric pressure (AAP), average temperature (AT), average vapor pressure (AVP), average relative humidity (ARH), monthly precipitation (MP), average wind speed (AWS), monthly total sunshine hours (MSH), mean temperature difference (MTD), rain day (RD) and average temperature distance (ATD), but the effect of meteorological factors might differ in various climate types.ConclusionsSpatial panel data models are useful and effective when longitudinal data are available and spatial autocorrelation exists. Our findings showed that meteorological factors were related to the occurrence of HFMD, which were also affected by climate type.
Highlights
Major outbreaks of hand, foot and mouth disease (HFMD) have been reported in China since 2008, posing a great threat to the health of children
It has been found that temperature and relative humidity were positively associated with HFMD in most studies [6,7,8,9,10,11], whereas studies in Japan found that the number of days per week with an average temperature above 25°C was negatively associated with HFMD incidence [12]
The number of reported cases for each month is shown in Fig. 2, which indicates a potential seasonality of the incidence of HFMD, since more cases occurred in April-July
Summary
Foot and mouth disease (HFMD) have been reported in China since 2008, posing a great threat to the health of children. Many studies have examined the effect of meteorological variables on the incidence of HFMD, the results have been inconsistent. This study aimed to quantify the relationship between meteorological factors and HFMD occurrence in different climates of mainland China using spatial panel data models. The trend of HFMD outbreaks has increased among children in China, which is regarded as an important public health problem [4, 5]. Many studies have been performed to analyze the association between meteorological factors and HFMD, but the results have been inconsistent. Other possible risk factors (total sunshine, difference in temperature, atmospheric pressure, vapor pressure, etc.) were examined in a few studies and require further research
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