Different dose of pentazocine for postoerative patient-controlled intravenous analgesia after resection of breast cancer

Abstract

Objective To compare the clinical effect and safety of different dose of pentazocine for postoperative patient-controlled intravenous analgesia after resection of breast cancer. Methods A total of 90 patients of ASAⅠ-Ⅱundergoing resection of breast cancer were randomly divided into 3 groups(n=30/group). Group P1 was administered with continuously intravenous pentazocine at 0.04 mg/(kg·h) after operation, group P2 pentazocine 0.05 mg/(kg·h) and group P3 pentazocine 0.06 mg/(kg·h).Visual analogue scale(VAS), Prince-Henry, sedation scores and vital signs(MAP, HR, RR, SpO2) were assessed after 4,12,24,48 hours of postoperative analgesia. The scores of satisfaction of postoperative analgesia and the adverse reactions including nausea, emesis, pruritus and resperitory inhibition were recorded after 48 hours of postoperative analgesia.Results After 4,12,24 and 48 hours of postoperative analgesia, VAS scores were higher in group P1 than that in group P2 and group P3(P 0.05).Conclusions Pentazocine 0.05 mg/(kg·h) for postoperative analgesia after resection of breast cancer provides better analgesia effect and few adverse reaction. Key words: Breast cancer ; Pentazocine ; Postoperative analgesia ;