Abstract
Background Trimeric gp41 might be an important target for neutralizing antibodies; however, the poor immunogenicity of this region may be due to its lack of exposure on native virus. CD154 (CD40L) is a trimeric glycoprotein found on activated CD4 T-cells that binds to CD40 on APCs and leads to B-cell activation and differentiation to plasma cells. We designed a novel immunogen with the potential for inducing neutralizing antibodies to gp41 and for stimulating activity on APC and B-cells.
Highlights
Trimeric gp41 might be an important target for neutralizing antibodies; the poor immunogenicity of this region may be due to its lack of exposure on native virus
CD154 (CD40L) is a trimeric glycoprotein found on activated CD4 T-cells that binds to CD40 on APCs and leads to B-cell activation and differentiation to plasma cells
PBMCs from SIV naïve and immune macaques were exposed to wild type vaccinia viruses (VVs) (VVwt) or to recombinant VVs expressing SIV Gag, gp160, and Nef (VVgen), or SIV Gag and Nef, and CD154-gp41 fusion proteins
Summary
Trimeric gp might be an important target for neutralizing antibodies; the poor immunogenicity of this region may be due to its lack of exposure on native virus. CD154 (CD40L) is a trimeric glycoprotein found on activated CD4 T-cells that binds to CD40 on APCs and leads to B-cell activation and differentiation to plasma cells. We designed a novel immunogen with the potential for inducing neutralizing antibodies to gp and for stimulating activity on APC and B-cells
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