Different Associations between DC-SIGN Promoter-336G/A (rs4804803) Polymorphism with Severe Dengue in Asians and South-Central Americans: a Meta-Analysis.

Jiangping Ren,Enfu Chen,Zhengting Wang

doi:10.3390/ijerph16081475

Abstract

Objective: This study was conducted to identify the association between rs4804803 polymorphism in DC-SIGN with the susceptibility of severe dengue. Methods: A comprehensive search was conducted to identify all eligible papers in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Google Scholar. Odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were used to assess the association. Subgroup analyses were performed by ethnicity. Sensitivity analyses were performed through employing different statistical models (fixed versus random effect model). Results: A total of nine papers and 12 studies, with 1520 severe dengue and 1496 clinical dengue infection were included. The overall meta-analysis revealed significant associations between rs4804803 and severe dengue under the recession (GG versus GA/AA: OR = 0.44, 95%CI, 0.23–0.82) and a codominant model (GG versus AA: OR = 0.43, 95%CI, 0.23–0.81), but sensitivity analysis indicated that the significant pooled ORs were not robust. The subgroup analysis suggested that the carrier of G in rs4804803 was a risk factor for severe dengue under dominant (GG/GA versus AA: OR = 1.86,95%CI, 1.01–3.45), superdominant (GA versus GG/AA: OR = 1.81,95%CI, 1.02–3.21) and a codominant (GA versus AA: OR=1.82,95%CI, 1.02–3.26) models in Asians, while it was a protective factor for severe dengue in South-central Americans under recessive (GG versus GA/AA: OR = 0.27,95%CI, 0.10–0.70) and codominant (GG versus AA: OR=0.24,95%CI, 0.09–0.64) models. The results from subgroup analysis were robust. Conclusions: Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) promoter-336G/A (rs4804803) polymorphism is association with severe dengue, and it acts in different directions for Asians and South-central Americans.

Highlights

Dengue is the most prevalent mosquito-borne infectious disease, which is endemic more than 125 countries around the world, especially South-East Asia, the Americas, the Western Pacific and Africa
A total of 239 papers were identified through database searching, and 122 of them were excluded for duplication (Figure 1)
Two papers were removed after reading: one paper had no data about rs4804803 [34]; another paper was a study about the persistence of dengue clinical symptoms [35]

Summary

Introduction

Dengue is the most prevalent mosquito-borne infectious disease, which is endemic more than 125 countries around the world, especially South-East Asia, the Americas, the Western Pacific and Africa. In the past 50 years, the incidence has increased 30 fold and the affected area has extended to new countries and from urban to rural settings [1]. It is estimated that about half of the world’s population is at risk. The most recently published study about the global burden of dengue indicated that there were 58.4 million (23.6 million–121.9 million) apparent cases with incidence of 810·1. Res. Public Health 2019, 16, 1475; doi:10.3390/ijerph16081475 www.mdpi.com/journal/ijerph

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