Abstract
(1) Background: The regenerative procedure has established a new approach to root canal therapy, to preserve the vital pulp of the tooth. This present review aimed to describe and sum up the different approaches to regenerative endodontic treatment conducted in the last 10 years; (2) Methods: A literature search was performed in the PubMed and Cochrane Library electronic databases, supplemented by a manual search. The search strategy included the following terms: “regenerative endodontic protocol”, “regenerative endodontic treatment”, and “regenerative endodontics” combined with “pulp revascularization”. Only studies on humans, published in the last 10 years and written in English were included; (3) Results: Three hundred and eighty-six potentially significant articles were identified. After exclusion of duplicates, and meticulous analysis, 36 case reports were selected; (4) Conclusions: The pulp revascularization procedure may bring a favorable outcome, however, the prognosis of regenerative endodontics (RET) is unpredictable. Permanent immature teeth showed greater potential for positive outcomes after the regenerative procedure. Further controlled clinical studies are required to fully understand the process of the dentin–pulp complex regeneration, and the predictability of the procedure.
Highlights
Introduction distributed under the terms andTissue engineering is a fast-growing scientific field connecting the principles of medicine, engineering, and biology to replace, restore, or regenerate tissues damaged or lost due to disease and/or trauma [1,2]
Retrieved data from the analyzed studies are described in Table 1. reports wereInselected
The presented data in this review showed that the pulp revascularization procedure may bring a favorable outcome, the prognosis of regenerative endodontics (RET) is unpredictable
Summary
Introduction distributed under the terms andTissue engineering is a fast-growing scientific field connecting the principles of medicine, engineering, and biology to replace, restore, or regenerate tissues damaged or lost due to disease and/or trauma [1,2]. Studies indicate that dental pulp contains five types of mesenchymal stem cells (MSCs) [7], which are noteworthy because of their pluripotent properties and easy method of isolation from exfoliated deciduous teeth [8]. It has been suggested, that dental pulp stem cells have the ability to differ into teeth tissues, but that they have a neuronal and muscular differentiation capacity, and may play a key role in the future medical treatment of various diseases [9]. The following sources of stem cells in human dental pulp have been characterized [3,10,11]: conditions of the Creative Commons
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