Abstract
Purpose: The aim of the study was to find an appropriate method for determination of the attachment degree of polyethylene glycol (PEG) to poly(anhydride) nanoparticles. Methods: The nanoparticles were modified with hydroxy-functionalized or with amino-functionalized PEGs. Three methods for their determination were applied and examined: in particular colorimetry, nuclear magnetic resonance (H-NMR), and elemental analysis (EA). Results: The attachment degrees determined by H-NMR and colorimetry were similar. The associated amounts of PEGs estimated on the basis of EA differed significantly than those determined by colorimetry and H-NMR. Conclusion: The colorimetric determination was considered fast and simple technique, but H-NMR contributed to more precise results.
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