Abstract
Background and Aim: Telomeres are repetitive DNA sequences localized at the ends of eukaryotic chromosomes. These unique structures are composed of telomeric DNA and telomere-associated proteins. Of telomere-associated proteins, telomeric repeat factor 1 (TRF1) and 2 (TRF2) bind double-stranded telomeric DNA to regulate telomeres length throughout cellular lifespan. On the other hand, protection of telomeres 1 (POT1) interacts with single-stranded telomeric DNA and contributes to protecting genome integrity.
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