Abstract
The consumption of fructose has increased dramatically during the last two decades and parallels the epidemics of obesity, metabolic syndrome, diabetes and chronic kidney disease ADDIN EN.CITE ADDIN EN.CITE.DATA . Fructose comes naturally e.g. in fruit and in honey, both sole as monosaccharide and as sucrose. High-fructose corn syrup is an American substitute for sucrose containing 55% fructose. 6 HD-patients and 9 healthy subjects consumed 190 ml cream and 75 g sucrose. Fructose and uric acid were analyzed postprandially during 240 min. For this study we used a new sensitive fructose assay. Fat/carbohydrate loading resulted in different acute fructose responses (see figure) and whereas uric acid levels remained stable in controls, it increased by 10 % in HD patients. We conclude that a fatty meal is associated with a delayed post-prandial fructose absorption and/or metabolism, as well as increased uric acid levels in HD patients. In an ongoing new study, the fructose metabolism will be further studied in CKD patients, diabetics and healthy controls.
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