Abstract
The nature of signals transmitted by two Fcγ receptors (Fcγ 2R for IgG2 and Fcγ 1/γ 2R for both IgG2 and IgG1) on guinea pig polymorphonuclear leukocytes was investigated. The specific binding of hen ovalbumin (OA)-complexed IgG1 antibody to Fcγ 1/γ 2R did not seem to trigger the release of [ 3H]arachidonic acid from the cells prelabeled with [ 3H]arachidonic acid. In contrast, marked release occurred on the binding of OA-complexed IgG2 antibody to the cells. This reaction was not inhibited, but rather enhanced, by the Fab′ of a monoclonal antibody to Fcγ/γ 2R. Therefore, a signal for the activation of the arachidonic acid metabolic cascade was found to be transmitted by Fcγ 2R, but scarcely by Fcγ 1/γ 2R.
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