Abstract
Lemongrass is one of the plants that widely used as traditional medicine in Indonesia. Lemongrass contains bioactive substances such as flavonoids, phenolic acids and tannins which act as anti-inflammatory and antioxidants that influence the wound healing process. The aim of this study was to compare the differences in buccal and labial mucosal wound healing, and to see the effect of lemongrass extract on the process of increasing oral mucosal epithelial thickness in white rats. This research is a pure experimental design with a post test-only design with control design. This study used 21 white rats divided into 3 groups where the first group of 100% lemongrass extract, the second group of 50% lemongrass extract, and the third group as the treatment that was not treated. The results of the One-way ANOVA and Post-hoc LSD test on the buccal mucosa showed significant differences with the labial mucosa. There were no significant differences in the buccal section with the second group and the third group p = 0.74 (p <0.05). There were no significant differences in the labial section with the first and second groups, but there were significant differences with the third group p = 0.003 (p <0.05). The effect of lemongrass extract has effectiveness in accelerating healing of oral mucosal wounds in white rats. There was also an increase in the thickness of the oral mucosal epithelium after administration of lemongrass extract with concentrations of 100% and 50%. Based on the research that has been done it can be concluded that healing wounds of the buccal mucosa heal faster than labial mucosal wounds because the buccal part contains saliva which has an important role in the wound healing process.
Highlights
Lemongrass has active substances such as alkaloids, flavonoids, saponins, tannins, pheonolic acid, and terpenoids
While the lamina propria is a layer of fibers that are mutually bound and function to provide strength to the epithelial layer Epithelial cells are the cells keratinocytes largely different from the lamina propria is a loose connective tissue formed under the epithelium consisting of fibroblast cells, lymphocytes, macrophages, eosinophilic leukocytes, mast cells and plasma cells, small blood vessels and glands
Laboratory experimental studies on extracts of lemongrass (Cymbopogon ciratus) on wound healing in mice oral mucosa is to prove that the extracts of lemongrass has a length of wound healing effect, the role of saliva on wound healing and increase the thickness of the epithelium
Summary
Lemongrass has active substances such as alkaloids, flavonoids, saponins, tannins, pheonolic acid, and terpenoids. Flavonoids, pheonolic acid and tannins in lemongrass has antimicrobial and antibacterial substances that work as antioxidants to inhibit spending free radicals such as cyclooxygenase (COX), lipooxygenase, and inducible Nitric Oxide Synthase (iNOS) and changing the intracellular pathways in cells imun [2]. The oral mucosa contains two layers namely the epithelium and connective tissue (lamina propria) [3]. The oral epithelium is the outermost layer of the mucosa that functions as a protection for the underlying layer. Regeneration of the epithelium derived from mitosis occurs in the epithelial cells are pushed to the top layer which do not have a cell nucleus and increasingly thinner [4,5]
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