Abstract

Aim of the study was to examine cardiorespiratory parameters at individual ventilatory threshold (IVT) and peak exercise capacity () in outpatient diabetic and sarcopenic obese subjects. Seventeen obese subjects (BMI: 36.6 ± 4.1 kg·m−1) and sixteen SO subjects (BMI: 37.0 ± 7.3 kg·m−1) were compared with sixteen T2DM subjects (BMI: 37.7 ± 5.6 kg·m−1). All groups performed an incremental exercise test on a treadmill according to their physical ability. , %HRmax, and maximal metabolic equivalent (METmax) were evaluated at maximal effort. Moreover, , %, %HRmax, %HRR, ΔHR, and METivt were assessed at IVT. No significant differences were found in any physiological parameters at maximal effort (, %HRmax, and METmax) in all groups. On the contrary, , %, %HRmax, %HRR, ΔHR, and METivt were significantly lower in T2DM subjects as compared to OB and SO subjects at IVT (p < 0.05). Our results show that while at maximal effort there are no differences among groups, at IVT the physiological parameters are lower in T2DM subjects than in OB and SO subjects. Therefore, due to the differences observed in the groups, we suggest usng the IVT as a useful parameter to prescribe aerobic exercise in obese with sarcopenia or diabetes mellitus conditions.

Highlights

  • Obesity is one of the greatest public health challenges of the 21st century

  • Our results show that while at maximal effort there are no differences among groups, at individual ventilatory threshold (IVT) the physiological parameters are lower in type 2 diabetes mellitus (T2DM) subjects than in OB and SO subjects

  • Further biochemical evaluation showed that glycated hemoglobin was 49.9 ± 8.3 mmol/mol in T2DM group, while no alterations in glycemic values were found in subjects of the other 2 groups

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Summary

Introduction

Between 1980 and 2008, the worldwide prevalence of obesity almost doubled [1]. Obesity drastically increases the individual risk of developing chronic metabolic diseases, such as cardiovascular disease, cancer, and diabetes mellitus. Type 2 diabetes mellitus (T2DM) is a worldwide pathological condition associated with obesity and sedentary lifestyle [2]. Adipose tissue excess and physical inactivity have led to the development of a pathological condition defined as “sarcopenic obesity.”. Sarcopenic obesity prevalence ranges from 2.75% to over 20%, depending on the criteria used for the diagnosis and methods of body composition assessment [3]. Sarcopenic obesity condition is commonly observed in older people [6] but, more recently, it can be observed in younger adults, likely linked to physical inactivity and sedentary behavior [6, 7]

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