Differences in the recovery rate of a learned forelimb movement after ablation of the motor cortex in right and left hemisphere in white rats

Abstract

After ablation of the motor cortex contralateral to the preferred limb, rats were forced to use this limb in grasping food out of a horizontal tube by restraining the non-preferred foreleg with a bracelet. In a right-handed rat the motor behaviour is less impaired and the recovery is better after a left hemisphere lesion in comparison with a left-handed rat after a right hemisphere lesion. This difference is primarily the time needed to use the limb in reaching for seed (testperiod 3) and the total time needed for 10 successive seizings of seed (testperiod 5). Surprisingly, the differences in the course of recovery do not correlate with the degree of preoperative limb preference: the initially ambidextrous rate also show the same differences in results of the motor cortex ablation in left and right hemisphere. However, in the group of initially consistent ambidextrous rats, after 10 weeks of tests with a restrained forelimb, the testing under unrestrained free conditions shows a gradual decrease in the induced limb preference and a shift to the use of the foreleg contralateral to the intact hemisphere, while in contrast the initially consistent left- or right-handed rats preserve the limb preference under the unrestrained testing conditions. Therefore the degree of initial preference still influences the choice of limb after motor cortex ablation and intensive training to use the ‘damaged’ limb.