Abstract
Sequence analysis of a region extending between the pVIII and the fiber gene of Canine adenovirus type 1 (Cav-1, Utrecht) and type 2 (Cav-2, Manhattan) was performed. The results revealed a high level of identity between the two viruses when the pVIII gene and the N-terminal part of the fiber gene were compared. The open reading frames of region E3 in of Cav-1 and Cav-2 encoded a 22 kDa and 40.7 kDa polypeptide, respectively. The Cav-1 and Cav-2 E3 region polypeotides shared conserved amino and carboxyl domains. In Cav-2 an extra sequence of about 500 nucleotides was present, appearing like an in frame insertion of foreign DNA. It can be speculated that this insertion in the E3 region contributes to the observed biological differences between Cav-1 and Cav-2.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
