Differences in symmetrical low-frequency oscillations among healthy subjects, and those with stroke or peripheral arterial disease

Abstract

ObjectiveLow-frequency oscillations (LFOs) observed in near-infrared spectroscopy (NIRS) reflect autonomic physiological processes, and may serve as useful indicators for detecting and monitoring circulatory dysfunction. The aim of this study was to reveal whether LFOs can be used as vascular perfusion biomarkers to differentiate different types and degrees of vascular lesions based on clinical patient data. Materials and Methods: In this study, healthy controls, ischemic stroke patients and peripheral atherosclerosis patients completed a resting-state LFO detection experiment. LFOs were collected simultaneously at peripheral right and left earlobes, fingertips and toes, along with coherence and phase shift analyses processing. Results: The results showed that the coherence coefficients of symmetric peripheral positions and the absolute value-phase shifts of fingers and toes can be used to distinguish healthy individuals, ischemic stroke patients and peripheral atherosclerosis patients. The symmetric earlobes’ absolute value-phase shifts could be used to differentiate mild and severe ischemic stroke patients; the coherence coefficients and absolute value-phase shifts of the symmetric toes could be used to differentiate mild and severe peripheral arteriosclerosis patients. The accuracy of differentiating between types of patients was 70%; those with different degrees of peripheral atherosclerosis was 85%, and those with different degrees of ischemic stroke was 72%. Conclusions: LFOs can serve as vascular perfusion biomarkers to differentiate types and degrees of vascular lesions. Therefore, LFOs have the potential to provide valuable patient information to assist researchers and clinicians in identifying specific peripheral circulatory damage subgroups.