Abstract
Objectives: Previous research from this and other laboratories has suggested a correlation between the subtle rise in Progesterone (P) induced by the administration of hCG, and cycle outcome in patients undergoing in vitro fertilization with embryo transfer (IVF-FT). The data suggests patients who have <2-fold increase in P following hCG will not conceive on that IVF-ET attempt (Poor responders; PR). Further, if the luteinizing-granulosa cells (LGC) of PR are placed in culture, their steroid hormone production will be significantly less than the LGC of patients with a normal response to hCG (>3-fold; NR). Recent studies have demonstrated steroidogenic acute regulatory protein (StAR) regulates the rate-limiting step in steroid hormone biosynthesis. The objective of the present study was to determine if StAR expression differed in NR and PR patients undergoing IVF-ET.
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