Abstract
Release of myeloperoxidase and β-glucuronidase from HL-60 cells in response to N-formyl-methionyl-leucyl-phenylalanine (fMet-Leu-Phe) in the presence of cytochalasin B was studied after induction of differentiation of the cells into granulocytes. Release of β-glucuronidase was observed with neither uninduced nor induced cells, whereas myeloperoxidase release was observed with induced cells but not with uninduced ones. In addition, chemotaxis and chemokinesis of the induced cells in response to this peptide were detected. These results suggest that there is a difference in release between myeloperoxidase and β-glucuronidase in the differentiated HL-60 cells, although the cells can respond to fMet-Leu-Phe.
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