Abstract
IntroductionThe present data on the evaluation of platelet (PLT) parameters in Chinese Han population and Tibetans are still limited. The objective of this study was to determine the differences in common PLT indices between Han population and Tibetans in China, through a large-scale investigation of healthy people.Methods2131 Han people from Chengdu Plain, 1099 Tibetans from Qinghai-Tibet Plateau and 956 Plateau Han migrants were included in this study. All the subjects were healthy people through the health screening. PLT indices were measured with Sysmex XE-2100 and XT-1800i blood cell automatic analyzer.ResultsCompared with Han people in Chendu Plain, Tibetans had higher PLT count (P<0.01) but lower mean platelet volume (MPV), platelet distribution width (PDW) and platelet-large cell ratio (P-LCR) (P<0.01); while Plateau Han migrants had lower PLT count, MPV and P-LCR (P<0.05). When compared with Tibetans, Plateau Han migrants had lower levels of mean PLT count but higher PDW and P-LCR (P<0.05).ConclusionsThere are ethnic differences in PLT indices between Chinese Han population and Tibetans. Based on this finding, it would be reasonable to conduct formal prospective studies to determine the clinical significance of these differences and to explore the effects of genetic background on these indices.
Highlights
The present data on the evaluation of platelet (PLT) parameters in Chinese Han population and Tibetans are still limited
When compared with Plateau Han migrants, mean PLT count, Mean platelet volume (MPV) and platelet-large cell ratio (P-LCR) of Han people in plain was significantly higher (P,0.05), while there was no obvious difference of platelet distribution width (PDW) between these two groups (P.0.05)
While MPV were positively correlated with either PDW (r = 0.946, P,0.001, Fig. 2D) or P-LCR (r = 0.990, P,0.001, Fig. 2E)
Summary
The present data on the evaluation of platelet (PLT) parameters in Chinese Han population and Tibetans are still limited. Chinese Tibetans have lived in a very high altitude (mean 4500 m) and hypoxic environment at the Qinghai-Tibet Plateau for thousands of years. They have a suite of distinctive physiological traits that enable them to tolerate the extreme environment, such as decreased arterial oxygen content [1] and limited increased red blood cell (RBC) counts and hemoglobin concentration [2]. Clinical monitoring of PLT amount and activity mainly rely on the determination of PLT indices including PLT count, Mean platelet volume (MPV), platelet distribution width (PDW) and platelet-large cell ratio (P-LCR), among which PLT count is the most common and important parameter. These indices, especially MPV and PDW, are reported to correlate with platelet function and may be more sensitive indices than platelet count as markers of clinical interest in various disorders, including some cardio- and cerobro-vascular diseases [4,6]
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