Abstract
SummaryThe results of these experiments indicate that basal levels of activity of hepatic microsomal drug metabolizing enzyme systems from various rabbit strains can vary as much as 20-fold in the strains studied. This is particularly true of hexobarbital, amphetamine, and aminopyrine metabolism where the widest variations were observed. Relatively little strain variation was seen in the basal metabolism of chlorpromazine. The wild rabbits and California rabbits exhibited the greatest differences from other rabbit strains in basal hepatic drug metabolism.A wide range of variability was also observed in the response of hepatic drug metabolizing enzyme systems to in vivo pre-treatment with phenobarbital. Especially noteworthy were the 26-fold increase in hexobarbital metabolism seen with the hepatic enzyme systems of Cottontails, the 7.5-fold increase in metabolism of p-nitrobenzoic acid in Jack rabbits, and the significant increases in 3,4-benzpyrene metabolism observed only in the wild rabbits. Also inter...
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
